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Tier

SNAP-8 (Acetyl Octapeptide-3)

SNAP-8 (Acetyl Octapeptide-3)

SNAP-8 (Acetyl Octapeptide-3)

Elongated octapeptide successor to Argireline for expression lines.

Skin & Beauty

Peptide, 8 amino acids

WADA Status:

Not listed

Human Trial Scoreboard

Completed human RCTs

0
0
0

Count not verified

Largest Human Study

0
0
0

Size not verified

Longest exposure

0
0
0

Duration not verified

Most Recent Trial

0
0
0

Year not verified

Description

SNAP-8, or acetyl octapeptide-3, is an eight amino acid cosmetic peptide developed as an extended version of argireline, with two additional amino acids intended to improve its activity. It is proposed to work the same way, by interfering with the signalling that triggers muscle contraction in the skin, and it carries the same topical Botox framing and the same problem with it. The evidence is limited to cosmetic testing rather than controlled clinical trials, and the effect is modest. It sits in the legitimate but oversold category: a genuine cosmetic ingredient whose marketing invites a comparison it cannot support.

What Are The Claims

Claims made for this compound: Targets the SNAP-25 mechanism to soften expression lines; Marketed as deeper-acting than Argireline; Topical and non-invasive

Evidence

Marketed as an extension of Argireline's mechanism, with a thinner published base than Argireline itself.

Evidence Strength

Traditional/anecdotal (minimal verifiable data)

Caveats

Cosmetic ingredient only; not FDA-approved as a drug; no independent clinical trials; essentially no Western replication of efficacy claims.

Safety
Alternative Measures
Legal Status

US

Cosmetic ingredient only

UK

Cosmetic ingredient only

EU

Cosmetic ingredient only

AU

Cosmetic ingredient only

WADA

Not listed

Cosmetic ingredient for topical use. Not a drug.

Citations

Manufacturer/cosmetic-industry data; minimal independent peer-reviewed human evidence.

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