E

Tier

MOTS-c

MOTS-c

MOTS-c

Mitochondrial-derived peptide acting as an exercise mimetic.

Longevity & Cellular Health

Peptide

WADA Status:

Not listed

Human Trial Scoreboard

Completed human RCTs

0
0
0

No interventional trial

Largest Human Study

0
0
0

Observational only

Longest exposure

0
0
0

None studied

Most Recent Trial

0
0
0

Year not verified

Description

MOTS-c is a genuinely interesting piece of biology. Mitochondria carry their own small genome, separate from the DNA in the cell nucleus, and MOTS-c is a short peptide encoded within it. It appears to be involved in how cells manage energy and respond to metabolic stress, and human studies have found that levels rise with exercise, which is a real finding. That finding is also the entire foundation of the marketing, and it does not say what the marketing implies. Observing that a molecule increases naturally when you exercise is a completely different claim from demonstrating that injecting it produces benefits. No trial has ever administered MOTS-c to a human being. The distance between those two statements is the whole story here.

What Are The Claims

Claims made for this compound: Activates AMPK to improve insulin sensitivity and glucose uptake (animal); Proposed exercise-mimetic and endurance effects; May support metabolic health with age

Evidence

The mitochondrial-derived peptide biology is legitimately interesting research. The leap from that to a marketed injectable for metabolism and performance is not supported by human data.

Evidence Strength

Animal/preclinical only

Caveats

Not FDA-approved; research compound; no interventional human trials; exercise and longevity claims are preclinical or associational only; not approved for human therapeutic use.

Safety
Alternative Measures
Legal Status

US

Not approved; removed from restricted compounding category April 2026 without approval

UK

Not approved

EU

Not approved

AU

Not approved

WADA

Not listed

Not approved. Research chemical with no completed human trials.

Citations

Lee et al. (2015). Cell Metabolism. Mouse metabolic studies + human genetic-association work (verify PMID).

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