
E
Tier
Mitochondrial-derived peptide acting as an exercise mimetic.
Longevity & Cellular Health
Peptide
WADA Status:
Not listed
Human Trial Scoreboard
Completed human RCTs
No interventional trial
Largest Human Study
Observational only
Longest exposure
None studied
Most Recent Trial
Year not verified
Description
MOTS-c is a genuinely interesting piece of biology. Mitochondria carry their own small genome, separate from the DNA in the cell nucleus, and MOTS-c is a short peptide encoded within it. It appears to be involved in how cells manage energy and respond to metabolic stress, and human studies have found that levels rise with exercise, which is a real finding. That finding is also the entire foundation of the marketing, and it does not say what the marketing implies. Observing that a molecule increases naturally when you exercise is a completely different claim from demonstrating that injecting it produces benefits. No trial has ever administered MOTS-c to a human being. The distance between those two statements is the whole story here.
What Are The Claims
Claims made for this compound: Activates AMPK to improve insulin sensitivity and glucose uptake (animal); Proposed exercise-mimetic and endurance effects; May support metabolic health with age
Evidence
The mitochondrial-derived peptide biology is legitimately interesting research. The leap from that to a marketed injectable for metabolism and performance is not supported by human data.
Evidence Strength
Animal/preclinical only
Caveats
Not FDA-approved; research compound; no interventional human trials; exercise and longevity claims are preclinical or associational only; not approved for human therapeutic use.
Safety
Alternative Measures
Legal Status
US
Not approved; removed from restricted compounding category April 2026 without approval
UK
Not approved
EU
Not approved
AU
Not approved
WADA
Not listed
Not approved. Research chemical with no completed human trials.
Citations
Lee et al. (2015). Cell Metabolism. Mouse metabolic studies + human genetic-association work (verify PMID).