E

Tier

Humanin

Humanin

Humanin

Mitochondrial-derived cytoprotective peptide.

Longevity & Cellular Health

Peptide

WADA Status:

Not listed

Human Trial Scoreboard

Completed human RCTs

0
0
0

No interventional trial

Largest Human Study

0
0
0

Observational only

Longest exposure

0
0
0

None studied

Most Recent Trial

0
0
0

Year not verified

Description

Humanin is another peptide encoded inside mitochondrial DNA, discovered in research on brain tissue and studied for apparent protective effects on cells under stress. Like MOTS-c, the human research measures naturally occurring levels rather than testing administration, and studies have looked at how those levels relate to ageing and disease. Those are association studies, and they cannot tell you what happens if you introduce more of the peptide from outside. No interventional trial has been completed. It is a legitimate and active area of mitochondrial biology research that has not reached the stage of testing in people, and it is sold as though it had.

What Are The Claims

Claims made for this compound: Cytoprotective and metabolic signaling (animal and observational); Higher endogenous levels associate with better outcomes; Proposed neuroprotective and longevity effects

Evidence

Preclinical mitochondrial biology. Longevity claims are mechanistic speculation at this stage.

Evidence Strength

Animal/preclinical only

Caveats

Not FDA-approved; research compound; no interventional human trials; evidence limited to preclinical models and observational associations; not approved for human use.

Safety
Alternative Measures
Legal Status

US

Not approved

UK

Not approved

EU

Not approved

AU

Not approved

WADA

Not listed

Not approved. Research chemical, no human trials.

Citations

Mitochondrial-derived peptide; cytoprotective animal/in-vitro studies plus observational human associations.

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