
C
Tier
Potent ghrelin-receptor GH secretagogue with rapid desensitization.
Muscle & Performance
Peptide
WADA Status:
Prohibited at all times (S2)
Human Trial Scoreboard
Completed human RCTs
Count not verified
Largest Human Study
Size not verified
Longest exposure
Duration not verified
Most Recent Trial
Year not verified
Description
Hexarelin belongs to the growth hormone releasing peptide family, working through the ghrelin receptor to prompt growth hormone release. It attracted some research interest because of possible direct effects on heart tissue, separate from the growth hormone pathway, which distinguished it from its relatives. That line of investigation never produced an approved medicine and no substantial modern development programme survives. Like the other compounds in this group it does what it says on the hormone panel and has never been shown to deliver the physical outcomes people pursue it for. Its evidence base is a scattering of small early studies from decades ago, and it is now essentially a research chemical with a footnote in cardiology literature.
What Are The Claims
Claims made for this compound: Strongest acute GH release of the classic secretagogues; Preclinical cardioprotective signaling; Proposed short-term recovery and body-composition effects
Evidence
Small human pharmacokinetic and GH-release studies exist. Notably, tolerance to its GH effect develops quickly, which undercuts the sustained-use case it is sold on.
Evidence Strength
Preliminary (small human GH/PK)
Caveats
Not approved; rapid desensitization with repeated dosing; no outcome data.
Safety
Alternative Measures
Legal Status
US
Not approved
UK
Not approved
EU
Not approved
AU
Not approved
WADA
Prohibited at all times (S2)
Not approved. Research chemical. WADA-prohibited.
Citations
Small human GH-secretion/PK studies (1990s-2000s).