FOXO4-DRI is the compound behind one of the most widely shared images in longevity research: aged mice with visibly restored fur and improved physical function. That study, published in the journal Cell in 2017 by Peter de Keizer's laboratory, is real and rigorous. The mechanism is called senolysis, selectively killing senescent cells, which are damaged cells that stop dividing but refuse to die and instead sit in tissue releasing inflammatory signals. FOXO4-DRI disrupts a protein interaction those cells depend on for survival. Everything demonstrated for it was demonstrated in mice. There is no completed human trial and no confirmed first-in-human study. The photographs are genuine, and the conclusion people draw from them about human use is not supported.