
E
Tier
Oral NNMT inhibitor for fat metabolism (small molecule, not a peptide).
Weight Loss & Metabolic
Small molecule, not a peptide
WADA Status:
Not listed
Human Trial Scoreboard
Completed human RCTs
None completed
Largest Human Study
No human studies
Longest exposure
None studied
Most Recent Trial
No completed trial
Description
5-Amino-1MQ is not a peptide, despite appearing in peptide catalogues. It is a small molecule that inhibits an enzyme called nicotinamide N-methyltransferase, which is more abundant in fat tissue in obesity and appears to influence how fat cells handle energy. Blocking it in mice reduced fat mass without changing how much the animals ate, which is a genuinely interesting result and the reason anyone has heard of the compound. That is where the evidence stops. It has never been administered to a human being in a published trial, no registered first-in-human study exists, and the entire consumer case for it rests on rodent metabolism.
What Are The Claims
Claims made for this compound: Supports fat metabolism; Energy; NAD+ pathway support
Evidence
The NNMT-inhibition mechanism is interesting preclinical metabolic biology. Human evidence does not exist, and it is sold as though it does.
Evidence Strength
Animal/preclinical only
Caveats
Safety
Alternative Measures
Legal Status
US
Not approved
UK
Not approved
EU
Not approved
AU
Not approved
WADA
Not listed
Not approved. Research chemical, no completed human trials.
Citations
No completed peer-reviewed human clinical trial exists for this compound. Where a citation is absent below, that absence is the finding.